INMEST Treatment
Nerve Stimulation
Technology
for Home Use
INMEST is a drug-free method under investigation to support autonomic balance and reduce migraine attacks, with potential for other conditions.
Why New Approaches to Migraine Treatments Are Needed
Migraine affects hundreds of millions worldwide, making it one of the most common and disabling neurological conditions.
About 60% feel mistreated in their migraine care
>50% of migraine sufferers remain undiagnosed
Medication often causes side effects, including more headaches
Many patients stop treatment due to poor efficacy or tolerability
A new Innovative Medical Device Solution
Gentle, guided nerve stimulation at home with minimal side effects
Home Use Design
Intuitive handheld device designed for safe, independent use in the comfort of your home
Neuromodulation Technology
Gentle mechanical stimulation targeting the autonomic nerve system
Minimal Side Effects
Treatment approach with a reduced side effect profile compared to pharmaceutical interventions
PROPRIETARY TECHNOLOGY
INMEST Treatment Platform
Abilion’s intuitive handheld medical device system is designed for safe use at home. It is prepared for clinicians to monitor usage and symptoms development
Handheld Device
Wireless, battery-charged controller with a disposable soft catheter. Connects via Bluetooth to the app and logs all treatments for later analysis.
Mobile App
Guides patients through their treatment plan, tracks symptoms via questionnaires, and syncs treatment data to the cloud while supporting reminders and clinician contact.
Cloud System
Enables clinicians to personalize treatment schedules, select questionnaires, and monitor patient progress with secure access.
A Nobel Prize Application
Recent research highlights the crucial role of regulatory T-cells (Tregs), often described as the body’s “immune peacekeepers.” The 2025 Nobel Prize in Physiology or Medicine recognized their role in controlling immune responses and maintaining balance.
Real-world application: INMEST, that use nerve stimulation to enhance the body’s natural immune regulation without drugs or implants.
Evidence: A study published in Oxford Open Immunology shows that INMEST shifts immune patterns and influences T-cell regulation.
Potential impact: Could treat autoimmune and chronic inflammatory diseases safely, non-invasively, and without systemic side effects.
Proposed migraine mechanism: INMEST activate regulatory T-cells that reduce neuroinflammation and modulate migraine pathways, preventing attacks and enhancing brain resilience.
This medical device system is currently being investigated in clinical trials and is not yet available for commercial distribution. Protected world-wide by granted and pending patents and patented designs.